Anestho 500mg Injection

Thiopental Sodium for Injection is a thiobarbiturate, the sulfur analogue of Sodium Pentobarbital. The drug is prepared as a sterile powder and after reconstitution with an appropriate diluent is administered by the intravenous route. Thiopental Sodium is an ultra short-acting depressant of the central nervous system, which induces hypnosis and anesthesia, but not analgesia. It produces hypnosis within 30 to 40 seconds of intravenous injection. Recovery after a small dose is rapid, with some somnolence and retrograde amnesia. Repeated intravenous doses lead to prolonged anesthesia because fatty tissues act as reservoir; they accumulate Thiopental Sodium in concentrations 6 to 12 times greater than the plasma concentration, and then release the drug slowly to cause prolonged anesthesia. The half-life of the elimination phase after a single intravenous dose is three to eight hours. Approximately 80% of the drug in the blood is bound to plasma protein. Thiopental Sodium is largely degraded in the liver and to a smaller extent in other tissues, especially the kidney and brain. It has a pKa of 7.4; Biotransformation products of Thiopental are pharmacologically inactive and mostly excreted in the urine. Drug information sourced from Incepta Pharma.